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. 2016 Oct 8;7(51):84299–84313. doi: 10.18632/oncotarget.12520

Figure 5. Dicer rescue abrogated Dicer-knockdown-induced ccRCC cell migration, invasion and angiogenesis.

Figure 5

Western blot confirmed that Dicer expression in Dicer stable knocked down 786-O and ACHN cells was effectively rescued by Dicer expression plasmid when compared with respective controls (A). Dicer over-expression in Dicer stable knocked down 786-O and ACHN cells abrogated Dicer knockdown enhanced cell migration and invasion (B), the number of cell migration and invasion per field was counted in five random fields (n = 3/group) in 786-O and ACHN (C–D). The increased tube formation by HUVECs in the conditioned medium collected from Dicer stable knocked down 786-O and ACHN cells was abolished by Dicer over-expression (E). The number of tubes formed per field was counted in five random fields (n = 3/group) in 786-O and ACHN (F). Data were presented as mean ± SD, *P < 0.05, **P < 0.001; Analysis of Variance.