Table 2. Correlations between HIC1 promoter methylation and patient characteristics.

Clinical feature	n	HIC1
		Methylation frequency (%)	P	mRNA	P	protein	P
Lymph node metastasis
Yes	18	68.1 ± 3.3	0.001	0.100 ± 0.001	0.001	0.191 ± 0.031	0.001
No	22	56.4 ± 2.8		0.322 ± 0.043		0.601 ± 0.037
Sex
Male	14	63.1 ± 2.6	0.089	0.233 ± 0.043	0.137	0.434 ± 0.072	0.320
Female	26	60.9 ± 4.6		0.217 ± 0.019		0.408 ±0.078
Age (year)
< 45	25	56.5 ± 3.7	0.001	0.302 ± 0.034	0.001	0.535 ± 0.097	0.001
≥ 45	15	70.4 ± 4.1		0.092 ± 0.019		0.221 ± 0.007
Tumor size (cm)
< 3	24	61.1 ± 2.4	0.147	0.241 ± 0.025	0.080	0.442 ± 0.043	0.061
≥ 3	16	62.5 ± 3.5		0.222 ± 0.042		0.480 ± 0.080
TNM stage
I–II	28	58.6 ± 2.1	0.001	0.274 ± 0.028	0.001	0.494 ± 0.051	0.001
III–IV	12	68.9 ± 1.8		0.101 ± 0.010		0.237 ± 0.023
Capsule invasion
Yes	17	62.9 ± 2.9	0.136	0.213 ± 0.019	0.193	0.387 ± 0.077	0.064
No	23	60.7 ± 5.3		0.231 ± 0.053		0.439 ± 0.089