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. 2016 Sep 20;7(51):84575–84586. doi: 10.18632/oncotarget.12144

Figure 6. Schematic representation of the possible role of SHP1 in HCV-related liver transformation.

Figure 6

A. The up-regulation of LXRα, SREBP1c and FASN by HCV infection induces lipid accumulation, increasing SHP1 expression that, in turn interacts with NS5A, causing deregulation on the expression of EMT related proteins: HNF4-E, Cadherin and SNAIL. B. SHP1 silencing antagonizes lipid accumulation and the induction of EMT, restoring the basal levels of HNF4, E-Cadherin and SNAIL, in HCV infected cells.