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. 2016 Nov 5;7(51):84594–84607. doi: 10.18632/oncotarget.13141

Figure 3. GSI-I combined with ABT-737 inhibited the self-renewability of MICs.

Figure 3

Secondary sphere assays were performed with the indicated melanoma cell lines. (A) Bright-field images of secondary spheres. Scale bar = 100 μm (B) Visualization of the secondary sphere cells with the Ethidium Bromide/Acridine Orange (EtBr/AO). Scale bar = 100 μm. (C) Quantification of the number of secondary spheres. * indicates p < 0.05; ** indicates p < 0.01; *** indicates p < 0.001. For clarity, we have only marked those cell lines, where the combination is significantly different from DMSO as well as both single drug treatments.