Skip to main content
. 2016 Sep 30;7(51):84608–84622. doi: 10.18632/oncotarget.12358

Figure 7. Effects of HS06 on TCF4 signaling.

Figure 7

a. Luciferase reporter assay showing significant inhibition of TCF/LEF promoter activity with HS06 that is reversed in the presence of p38 inhibitor – SB201350 (SB) (5 μM). b. Quantitative RT-PCR analysis showing inhibition of β-catenin targets gene expression (LGR5, c-MYC and BMI-1) by HS06, which is significantly reversed by SB. GAPDH was used as housekeeping control. * p-value < 0.005 compared to vehicle control. # p-value < 0.005 compared to HS06.