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. 2016 Nov 8;7(51):84705–84717. doi: 10.18632/oncotarget.13224

Figure 3. KCNJ3 mRNA levels are upregulated in estrogen receptor positive breast cancer samples.

Figure 3

KCNJ3 mRNA expression levels in breast cancer patient samples of the TCGA according (A) to their PAM50 classification (n = 509), (B) to their estrogen and progesterone receptor status (n = 836), and (C) to their estrogen receptor status (n = 841; p < 0.001). Boxplots: Whiskers represent the 10th and the 90th percentile, crosses represent outliers, and the red line marks the mean value. Number of samples analysed is given in brackets above each box. A Kruskal Wallis test with Dunn's post-hoc tests for pairwise comparison was used for analysis in (A) and (B), and a Wilcoxon rank sum test in (C); p-values are given on top of each plot. (D) Scatter plot of KCNJ3 and ESR1 mRNA expression levels in breast cancer patient samples of the TCGA (n = 905). (E) Scatter plot of KCNJ3 and ESR1 mRNA expression levels in patient samples of the GEO data set GSE17705 (n = 298). Spearman rank correlation coefficients (rS) and p-values are given in the boxes of each plot. n.c.: normalized counts; log2 int.: log2 intensity; LumA: luminal A type; LumB: luminal B type; basal: basal type; Her2: Her2-enriched type; Normal: normal-like type; ER: estrogen receptor; PR: progesterone receptor; (−): negative; (+): positive.