Skip to main content
. 2016 Oct 14;7(51):84798–84809. doi: 10.18632/oncotarget.12656

Figure 2. C5aR-stimulation with rC5a promotes invasion of gastric cancer cells.

Figure 2

A., lower surfaces of an invasion membrane when MKN1 cells were assayed for invasion. B and C., rC5a significantly enhanced the invasive ability of MKN1 and MKN7 cells. D., rC5a did not enhance the invasive ability of AGS cells. E–H., suppression of C5aR-expression using two kinds of siRNA significantly decreased the invasive ability of MKN1 and MKN7 cells. I and J., W-54011, a C5aR-antagonist, significantly suppressed the invasive ability of MKN1 and MKN7 cells. C5aR, C5a receptor; rC5a, recombinant C5a; DMSO, Dimethyl sulfoxide; W-54011, C5aR-antagonist; *p<0.05; **p<0.01. NS, not significant.