Table 6. Meta-analysis of the XPC rs2228000, rs2228001, XPA rs1800975 and ERCC1 rs11615 polymorphism on breast cancer risk.

Variables	Cases/controls	Homozygote vs. wild type			Heterozygote vs. wild type			Dominant model			Recessive modeld
		OR(95% CI)	P value	Phb	OR(95% CI)	P value	Phb	OR (95% CI)	P value	Phb	OR(95% CI)	P value	Phb
XPC rs2228000
Total	3897/4877a	1.28(1.08-1.52)	0.004	0.228	1.01(0.92,1.10)	0.867	0.291	1.02(0.89,1.17)c	0.766	0.030	1.25(1.06, 1.47)	0.008	0.521
Ethnicities
Caucasian	570/676	0.95(0.59,1.51)	0.811	0.979	0.86(0.68,1.08)	0.196	0.983	0.87(0.69,1.09)	0.219	0.991	1.01(0.64,1.59)	0.981	0.990
Asian	1068/1052	1.73(1.30,2.31)	0.000	0.384	1.26(1.05,1.51)	0.015	0.803	1.37(1.15,1.64)	0.000	0.475	1.52(1.16,1.99)	0.002	0.349
Other	2259/3149	1.13(0.89,1.43)	0.318	0.748	0.97(0.86,1.08)	0.520	0.809	0.97(0.88,1.08)	0.597	0.557	1.14(0.90,1.43)	0.287	0.674
Source of control
PB	2364/3220	1.37(1.11,1.68)	0.003	0.107	1.09(0.97,1.22)	0.148	0.198	1.15(0.94,1.42)c	0.171	0.033	1.29(1.06,1.57)	0.010	0.266
HB	1533/1657	1.12(0.82,1.51)	0.485	0.642	0.91(0.79,1.04)	0.149	0.931	0.91(0.80,1.04)	0.164	0.717	1.15(0.86,1.56)	0.349	0.656
XPC rs2228001
Total	6176/6955	0.99(0.89,1.10)	0.850	0.343	0.97(0.90,1.05)	0.430	0.206	0.97(0.91,1.05)	0.470	0.180	1.01(0.91,1.11)	0.869	0.444
Ethnicities
Caucasian	1714/1613	0.85(0.70,1.05)	0.369	0.369	0.91(0.78,1.05)	0.194	0.608	0.89(0.78,1.03)	0.112	0.462	0.90(0.75,1.09)	0.279	0.485
African	814/753	0.90(0.60,1.35)	0.649	0.649	0.94(0.77,1.16)	0.567	0.308	0.94(0.77,1.14)	0.512	0.420	0.93(0.63,1.37)	0.716	0.513
Asian	1068/1052	1.14(0.87,1.49)	0.196	0.196	1.01(0.59,1.75)c	0.962	0.004	1.04(0.63,1.71)c	0.894	0.005	1.10(0.86,1.42)	0.446	0.826
Other	2580/3537	1.04(0.89,1.22)	0.298	0.298	0.99(0.88,1.10)	0.810	0.792	1.00(0.90,1.11)	0.998	0.891	1.06(0.92,1.21)	0.453	0.130
Source of control
PB	4587/5222	0.95(0.84,1.08)	0.441	0.377	0.95(0.87,1.04)	0.258	0.081	0.95(0.88,1.03)b	0.230	0.056	0.98(0.87,1.10)	0.691	0.795
HB	1589/1733	1.10(0.89,1.35)	0.371	0.336	1.03(0.89,1.20)	0.700	0.738	1.05(0.91,1.21)	0.523	0.971	1.09(0.91,1.32)	0.346	0.122
XPA rs1800975
Total	2619/2663	0.92(0.65,1.31)	0.649	0.003	1.07(0.78,1.48)	0.663	0.001	1.03(0.74,1.42)	0.873	0.000	0.94(0.84,1.06)	0.303	0.190
Ethnicities
Asian	1407/1409	0.82(0.54,1.26)	0.372	0.018	0.95(0.60,1.51)	0.841	0.002	0.91(0.58,1.43)	0.686	0.001	0.83(0.70,0.99)	0.039	0.539
Other	1212/1254	1.22(0.94,1.59)	0.129	0.255	1.30(1.01,1.66)	0.039	0.821	1.27(1.01,1.60)	0.046	0.795	1.05(0.89,1.23)	0.585	0.239
ERCC1 rs11615
Total	1012/1035	1.56(1.17,2.09)	0.003	0.717	1.31(1.09,1.58)	0.005	0.462	1.38(1.15,1.64)	0.000	0.781	1.44(1.10,1.90)	0.009	0.634

^ars2228000 cases/controls are not include the studies of Smith(b) and Perez-Mayoral

^bPh value of Q-test for heterogeneity test.

^cRandom-effects model was used when a P value < 0.05 for heterogeneity test; otherwise, fixed-effects model was used.

^dAvailable data by Tatemichi et al was used in stratified analyses by cancer type, ethnicity and source of control for the recessive model comparison.

PB: population based control studies; HB: hospital based control studies.