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. 2016 Oct 19;7(51):84872–84882. doi: 10.18632/oncotarget.12744

Table 6. Meta-analysis of the XPC rs2228000, rs2228001, XPA rs1800975 and ERCC1 rs11615 polymorphism on breast cancer risk.

Variables Cases/controls Homozygote vs. wild type Heterozygote vs. wild type Dominant model Recessive modeld
OR(95% CI) P value Phb OR(95% CI) P value Phb OR (95% CI) P value Phb OR(95% CI) P value Phb
XPC rs2228000
Total 3897/4877a 1.28(1.08-1.52) 0.004 0.228 1.01(0.92,1.10) 0.867 0.291 1.02(0.89,1.17)c 0.766 0.030 1.25(1.06, 1.47) 0.008 0.521
Ethnicities
Caucasian 570/676 0.95(0.59,1.51) 0.811 0.979 0.86(0.68,1.08) 0.196 0.983 0.87(0.69,1.09) 0.219 0.991 1.01(0.64,1.59) 0.981 0.990
Asian 1068/1052 1.73(1.30,2.31) 0.000 0.384 1.26(1.05,1.51) 0.015 0.803 1.37(1.15,1.64) 0.000 0.475 1.52(1.16,1.99) 0.002 0.349
Other 2259/3149 1.13(0.89,1.43) 0.318 0.748 0.97(0.86,1.08) 0.520 0.809 0.97(0.88,1.08) 0.597 0.557 1.14(0.90,1.43) 0.287 0.674
Source of control
PB 2364/3220 1.37(1.11,1.68) 0.003 0.107 1.09(0.97,1.22) 0.148 0.198 1.15(0.94,1.42)c 0.171 0.033 1.29(1.06,1.57) 0.010 0.266
HB 1533/1657 1.12(0.82,1.51) 0.485 0.642 0.91(0.79,1.04) 0.149 0.931 0.91(0.80,1.04) 0.164 0.717 1.15(0.86,1.56) 0.349 0.656
XPC rs2228001
Total 6176/6955 0.99(0.89,1.10) 0.850 0.343 0.97(0.90,1.05) 0.430 0.206 0.97(0.91,1.05) 0.470 0.180 1.01(0.91,1.11) 0.869 0.444
Ethnicities
Caucasian 1714/1613 0.85(0.70,1.05) 0.369 0.369 0.91(0.78,1.05) 0.194 0.608 0.89(0.78,1.03) 0.112 0.462 0.90(0.75,1.09) 0.279 0.485
African 814/753 0.90(0.60,1.35) 0.649 0.649 0.94(0.77,1.16) 0.567 0.308 0.94(0.77,1.14) 0.512 0.420 0.93(0.63,1.37) 0.716 0.513
Asian 1068/1052 1.14(0.87,1.49) 0.196 0.196 1.01(0.59,1.75)c 0.962 0.004 1.04(0.63,1.71)c 0.894 0.005 1.10(0.86,1.42) 0.446 0.826
Other 2580/3537 1.04(0.89,1.22) 0.298 0.298 0.99(0.88,1.10) 0.810 0.792 1.00(0.90,1.11) 0.998 0.891 1.06(0.92,1.21) 0.453 0.130
Source of control
PB 4587/5222 0.95(0.84,1.08) 0.441 0.377 0.95(0.87,1.04) 0.258 0.081 0.95(0.88,1.03)b 0.230 0.056 0.98(0.87,1.10) 0.691 0.795
HB 1589/1733 1.10(0.89,1.35) 0.371 0.336 1.03(0.89,1.20) 0.700 0.738 1.05(0.91,1.21) 0.523 0.971 1.09(0.91,1.32) 0.346 0.122
XPA rs1800975
Total 2619/2663 0.92(0.65,1.31) 0.649 0.003 1.07(0.78,1.48) 0.663 0.001 1.03(0.74,1.42) 0.873 0.000 0.94(0.84,1.06) 0.303 0.190
Ethnicities
Asian 1407/1409 0.82(0.54,1.26) 0.372 0.018 0.95(0.60,1.51) 0.841 0.002 0.91(0.58,1.43) 0.686 0.001 0.83(0.70,0.99) 0.039 0.539
Other 1212/1254 1.22(0.94,1.59) 0.129 0.255 1.30(1.01,1.66) 0.039 0.821 1.27(1.01,1.60) 0.046 0.795 1.05(0.89,1.23) 0.585 0.239
ERCC1 rs11615
Total 1012/1035 1.56(1.17,2.09) 0.003 0.717 1.31(1.09,1.58) 0.005 0.462 1.38(1.15,1.64) 0.000 0.781 1.44(1.10,1.90) 0.009 0.634
a

rs2228000 cases/controls are not include the studies of Smith(b) and Perez-Mayoral

b

Ph value of Q-test for heterogeneity test.

c

Random-effects model was used when a P value < 0.05 for heterogeneity test; otherwise, fixed-effects model was used.

d

Available data by Tatemichi et al was used in stratified analyses by cancer type, ethnicity and source of control for the recessive model comparison.

PB: population based control studies; HB: hospital based control studies.