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. 2016 Nov 4;7(51):84951–84964. doi: 10.18632/oncotarget.13069

Figure 1. PD 0332991 enhances the growth inhibitory effects of gefitinib in PC-9 and PC-9/AB2 cell lines.

Figure 1

A, B. PC-9 and PC-9/AB2 cells were exposed to different doses of gefitinib (A) and PD 0332991 (B) for 24 hr to evaluate the IC50 of these two cell lines. MTT assay was used to evaluate cell viability. C, D. There was a synergistic interaction between PD 0332991 (8 μmol/L) and gefitinib (16 μmol/L) in PC-9 cells (C) and PC-9/AB2 cells (D). Cells were treated with various concentrations of gefitinib in combination with PD 0332991 for 24 hr, and cell viability was measured by MTT assay. The concentrations of PD 0332991 and gefitinib used in this study were from CompuSyn software (Combosyn, Inc.).