Table 1. Overview of the samples and results.
Case/Lab Number | Diagnosisa | FHIT | miR-30c | LIN28A | LIN28Bd | Let-7a | HMGA2 |
---|---|---|---|---|---|---|---|
1/02-167 | SCC m | ↓ | ↓ | ↓ | - | ↓ | ↑ |
2/02-848 | SCC m | ↓ | ↓ | ↓ | - | ↓ | ↑ |
3/02-869 | SCC h, m, p | ↓ | ↓ | ↓ | - | ↓ | ↑ |
4/02-1171 | SCC | ↓ | ↓ | ↑ | - | ↓ | ↑ |
5/03-830 | SCC m | ↓ | ↓ | nec | - | ↓ | ↑ |
6/03-1011 | SCC h, m | ↑ | ↓ | nec | - | ↓ | ↑ |
7/03-1088 | SCC h | ↓ loss 3p14b* | ↓ | ↑ | - | ↓ | ↑ |
8/06-19 | SCC p | ↓ | ↓ | nec | - | ↓ | ↑ |
9/06-125 | SCC m | ↓ loss 3p14b | ↓ | ↑ | - | ↓ | ↑ |
10/09-733 | SCC h | ↓ loss 3p14b | ↓ | ↓ | - | ↓ | ↑ |
Arrows are used to show deregulation of the genes (arrow head up: up regulation; arrow head down: down regulation)
h: highly differentiated, m: moderately differentiated, p: poorly differentiated.
Genomic Imbalances assessed with an array based Comparative Genomic Hybridization (aCGH) showing a loss of the FHIT locus.
aCGH detected a homozigous deletion for the FHIT locus.
ne: normal expression (no differences between samples and the normal controls expression levels).
No LIN28B expression was found in our samples.