Table 2. Univariate and multivariate analysis of overall survival (OS) in hepatocellular carcinoma.

Variables	n	Univariate Analysis		Multivariate Analysis
		HR (95% CI)	P	HR (95% CI)	P
Age (years)
<50	44	0.791(0.455-1.374)	0.405
≥50	57
Gender
Female	46	0.726(0.418-1.259)	0.254
Male	55
Tumor size(cm)
<5	44	0.576(0.330-1.006)	0.053
≥5	57
Histologic grade
Poor	39	2.558(1.267-5.164)	0.009	2.377(1.164-4.854)	0.017
Moderate	32
Well	30
Liver cirrhosis
Absence	36	0.792(0.440-1.425)	0.437
Presence	65
Serum AFP (ng/ml)
≤400	35	0.914(0.524-1.594)	0.752
>400	66
BCLC stage
A	18	0.372(0.150-0.923)	0.033	0.480(0.169-1.364)	0.168
B	36
C	47
HBV
Negative	11	0.377(0.117-1.212)	0.102
Positive	90
Microvascular invasion
NO	54	0.546(0.316-0.942)	0.030	0.617(0.338-1.124)	0.115
Yes	47
IL-37 expression
High	51	0.496(0.285-0.863)	0.013	0.555(0.308-0.999)	0.050
Low	50

AFP, α-fetoprotein;BCLC stage, Barcelona Clinic Liver Cancer stage;HBV, hepatitis B virus;