Table 3. Univariate and multivariate analysis of Disease-free survival (DFS) in hepatocellular carcinoma.

Variables	n	Univariate Analysis		Multivariate Analysis
		HR (95% CI)	P	HR (95% CI)	P
Age (years)
<50	44	0.890(0.549-1.444)	0.638
≥50	57
Gender
Female	46	0.697(0.428-1.134)	0.228
Male	55
Tumor size(cm)
<5	44	0.560(0.340-0.923)	0.023	0.620(0.363-1.059)	0.080
≥5	57
Histologic grade
Poor	39	2.395(1.293-4.437)	0.005	2.263(1.212-4.225)	0.010
Moderate	32
Well	30
Liver cirrhosis
Absence	36	1.047(0.639-1.715)	0.855
Presence	65
Serum AFP (ng/ml)
≤400	35	0.765(0.462-1.267)	0.299
>400	66
Tumor staging(BCLC)
A	18	0.356(0.153-0.829)	0.017	0.869(0.342-2.209)	0.769
B	36
C	47
HBV
Negative	11	0.623(0.269-1.445)	0.270
Positive	90
Microvascular invasion
NO	54	0.527(0.325-0.853)	0.009	0.582(0.342-0.991)	0.046
Yes	47
IL-37 expression
High	51	0.516(0.315-0.845)	0.009	0.531(0.285-0.987)	0.045
Low	50

AFP, α-fetoprotein;BCLC stage, Barcelona Clinic Liver Cancer stage;HBV, hepatitis B virus;