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. 2016 Nov 16;7(51):85381–85392. doi: 10.18632/oncotarget.13377

Figure 5. Pin1 up-regulates the level of P2Y1 protein by increasing its half-life.

Figure 5

A. Protein levels of P2Y1 and Pin1 in MEF Pin1-/-, MEF Pin1+/+, JB6-GFP, and JB6-Pin1 cells. B, C. Half-life of P2Y1 in the presence of Pin1. Immunoblot analyses were performed using whole-cell extracts of MEF and JB6 cells treated with or without CHX at the indicated times. D, E. Migration of MEF Pin1-/-, MEF Pin1+/+, JB6-GFP, and JB6-Pin1 cells. The migration assays are described in the Materials and Methods section. The results represent the averages from three independent experiments.