Table 2. Pre-treatment diagnostics.

Pt #	Disease	MRI: brain parenchyma	MRI: leptomeninges	Neurologic Symptoms	CSF Cytology	CSF mutant cfDNA (copies/μL)	Plasma/urine mutant cfDNA (copies/μL)
1	Mel	+	+	-	-	0.512	P: 21
2	Mel	+	-	+	-	0	P: 0.8
3	Mel	+	-	+	-	0.219	P: 3.86
4	Mel	+	-	+	-	0	P: 0
5	Mel	+	-	+	-	0.15	P: 2.35
6	Mel	-	+	+	+	10.56	No samples
7	Mel	+	+	+	+	8.03	No samples
8	Mel	-	-	+	-	0	P: 174
9	ECD	-	-	+	-	0	U: 0.12
10	ECD	-	-	+	-	0.329	P: 0.76
11	ECD	+	-	+	-	0	P: .059

Mel: Melanoma, ECD: Erdheim-Chester Disease, P: Plasma, U: Urine.