Table 3. The associations between genetic polymorphisms and clinical characteristics of T2D.
SNP | genotype | n | HbA1c | TG | Cr | Cys-c | BMI | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
mean ± SD | p* | mean ± SD | p* | mean ± SD | p* | mean ± SD | p* | mean ± SD | p* | |||
rs2811893(MYSM1) | TT | 130 | 9.56±2.81 | 0.083 | 2.53±2.20 | 0.906 | 71.18±38.63 | 0.006* | 0.87±0.26 | 0.975 | 24.79±3.59 | 0.495 |
CT | 148 | 9.15±1.98 | 2.51±2.19 | 61.95±18.39 | 0.87±0.56 | 24.90±3.36 | ||||||
CC | 40 | 8.68±1.66 | 2.68±2.37 | 11.93±1.89 | 0.86±0.17 | 25.52±3.24 | ||||||
rs13064954(Unknown) | AA | 4 | 10.95±2.03 | 0.343 | 7.59±5.17 | 0.001* | 66.47±21.70 | 0.584 | 0.85±0.20 | 0.615 | 25.27±3.94 | 0.555 |
GG | 257 | 9.22±2.40 | 2.53±2.20 | 64.67±27.78 | 0.85±0.23 | 24.82±3.52 | ||||||
AG | 58 | 9.25±1.99 | 2.22±1.51 | 68.94±31.10 | 0.97±0.84 | 25.35±3.06 | ||||||
rs17376456(KIAA0825) | AA | 280 | 9.35±2.38 | 0.039* | 2.56±2.91 | 0.6 | 65.56±29.67 | 0.88 | 0.87±0.44 | 0.526 | 24.92±3.49 | 0.884 |
GA | 39 | 8.53±1.78 | 2.36±1.49 | 64.83±15.70 | 0.83±0.20 | 25.00±3.44 | ||||||
rs7772697(Unknown) | TT | 223 | 9.18±2.40 | 0.455 | 2.61±2.38 | 0.584 | 65.88±29.90 | 0.916 | 0.88±0.48 | 0.779 | 25.25±3.48 | 0.028* |
CT | 85 | 9.51±2.26 | 2.39±1.83 | 64.48±25.11 | 0.85±0.19 | 24.09±3.34 | ||||||
CC | 11 | 8.85±1.23 | 2.08±0.90 | 63.29±18.46 | 0.83±0.30 | 24.69±2.28 | ||||||
rs3918227(NOS3) | CA | 49 | 8.96±1.74 | 0.338 | 2.00±1.07 | 0.117 | 63.85±18.03 | 0.664 | 1.02±0.91 | 0.045* | 25.09±3.53 | 0.075 |
CC | 270 | 9.31±2.42 | 2.63±2.35 | 65.76±29.82 | 0.84±0.23 | 24.89±3.43 | ||||||
rs4838605(ARHGAP22) | TT | 243 | 9.34±2.43 | 0.216 | 2.66±2.36 | 0.041* | 65.77±23.91 | 0.737 | 0.89±0.46 | 0.168 | 24.95±3.28 | 0.777 |
TC | 76 | 8.97±1.97 | 2.13±1.56 | 64.51±39.42 | 0.81±0.25 | 24.82±3.92 | ||||||
rs6214(IGF1) | TT | 72 | 10.10±3.34 | 0.006* | 2.51±2.36 | 0.155 | 61.03±15.20 | 0.319 | 0.85±0.27 | 0.571 | 25.10±3.43 | 0.803 |
CC | 105 | 8.98±1.86 | 2.22±1.60 | 66.57±26.55 | 0.90±0.63 | 24.76±3.51 | ||||||
TC | 142 | 9.03±1.91 | 2.78±2.48 | 66.90±34.05 | 0.85±0.26 | 24.96±3.41 |
HbA1C = glycosylated hemoglobin A1c; TG = triglyceride; Cr = creatinine; Cys-c = cystatin C; BMI= body mass index;
OR = odds ratio; 95%CI = 95 % confidence interval;
*p ≤ 0.05 indicates statistical significance.