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. 2016 Dec 21;8(2):1983–1992. doi: 10.18632/oncotarget.14077

Figure 3. The levels of NF-κB p65 and HO-1 were different between SAMR1 and SAMP8, While SS31 exerted anti-inflammatory effects.

Figure 3

Compared with SAMR1, the gene expression A. and protein levels B. of NF-κB p65 increased significantly in the SAMP8 compared to SAMR1 at the age of 10 months old. After SS31 administration, they were decreased and recovered to SAMR1 level (A, B). The downstream detoxifying and antioxidant enzyme HO-1 were increased both at gene expression C. and protein levels D. relative to SAMR1. After SS31 administration, these parameters were increased further. Data are mean ±SD, *P < 0.05, ** P < 0.01.