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Examples of energy-minimized RNA duplex start structures (in stereo) with the sequence 5′-rCGCXGCG:5′-rCGCAGCG. The central base X was an uridine (A), a 2,4-difluorophenyl (B) base analogue or a phenyl base analogue (C) and standard backbone sugar–phosphate structure. For clarity only heavy atoms are shown.
