Table 2. Risk of meningioma in relation to conditions of metabolic syndrome.
| Variable | Number of cases(%)(n=2,027) | Number of controls(%)(n=20,269) | Adjusted OR (95% CI)* |
|---|---|---|---|
| BMI (kg/m2) | |||
| < 18.5 | 21 (1.04) | 358 (1.8) | 0.63 (0.40–0.99) |
| 18.5–24.9 | 630 (31.1) | 6,710 (33.1) | 1.00 (reference) |
| 25.0–29.9 | 611 (30.1) | 5,825 (28.7) | 1.13 (1.00–1.27) |
| ≥ 30.0 | 439 (21.7) | 3,624 (17.9) | 1.33 (1.17–1.52) |
| Unknown | 326 (16.1) | 3,752 (18.5) | 0.94 (0.79–1.11) |
| p-value for trend | < 0.0001 | ||
| Arterial hypertension | 699 (34.5) | 5,960 (29.4) | 1.34 (1.20–1.49) |
| Systolic blood pressure | |||
| < 120 mmHg | 294 (14.5) | 3,142 (15.5) | 1.00 (reference) |
| 120–139 mmHg | 769 (37.9) | 7,571 (37.4) | 1.11 (0.96–1.29) |
| 140–159 mmHg | 637 (31.4) | 5,979 (29.5) | 1.18 (1.00–1.38) |
| 160–179 mmHg | 167 (8.2) | 1,638 (8.1) | 1.13 (0.91–1.40) |
| ≥ 180 mmHg | 48 (2.4) | 448 (2.2) | 1.19 (0.85–1.66) |
| Unknown | 112 (5.5) | 1,491 (7.4) | 0.79 (0.59–1.06) |
| p-value for trend | 0.040 | ||
| Diastolic blood pressure | |||
| < 80 mmHg | 755 (37.3) | 8,108 (40.0) | 1.00 (reference) |
| 80–89 mmHg | 852 (42.0) | 7,930 (39.1) | 1.16 (1.05–1.29) |
| 90–99 mmHg | 251 (12.4) | 2,236 (11.0) | 1.23 (1.05–1.43) |
| ≥ 100 mHg | 57 (2.8) | 504 (2.5) | 1.25 (0.94–1.66) |
| Unknown | 112 (5.5) | 1,491 (7.4) | 0.80 (0.61–1.05) |
| p-value for trend | 0.013 | ||
| Dyslipidemia | 228 (11.3) | 2,110 (10.4) | 1.13 (0.96–1.32) |
| HDL-cholesterol | |||
| ≥ 60 mg/dl | 274 (13.5) | 2,653 (13.1) | 1.00 (reference) |
| 40–59 mg/dl | 357 (17.6) | 3,239 (16.0) | 1.08 (0.91–1.28) |
| < 40 mg/dl | 91 (4.5) | 851 (4.2) | 1.08 (0.83–1.40) |
| Unknown | 1,305 (64.4) | 13,526 (66.7) | 0.88 (0.75–1.04) |
| p-value for trend | 0.287 | ||
| Triglycerides | |||
| < 150 mg/dl | 471 (23.2) | 4,387 (21.6) | 1.00 (reference) |
| 150–199 mg/dl | 136 (6.7) | 1,257 (6.2) | 1.01 (0.83–1.24) |
| ≥ 200 mg/dl | 137 (6.8) | 1,388 (6.9) | 0.93 (0.76–1.14) |
| Unknown | 1,283 (63.3) | 13,237 (65.3) | 0.86 (0.75–0.98) |
| p-value for trend | 0.535 | ||
| Serum glucose+ | |||
| < 100 mg/dl | 219 (10.8) | 2,019 (10.0) | 1.00 (reference) |
| 100–126 mg/dl | 68 (3.4) | 627 (3.1) | 1.01 (0.76–1.35) |
| ≥ 126 mg/dl | 45 (2.2) | 460 (2.3) | 0.91 (0.65–1.28) |
| Unknown | 1,695 (83.6) | 17,163 (84.7) | 0.88 (0.73–1.05) |
| p-value for trend | 0.547 | ||
*
Matching variables: age, sex, general practice, and number of years of active history in the database. All analyses were adjusted for smoking, history of myocardial infarction, and estrogen use (among women).
+
Serum glucose was fasting.