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. 2016 Nov 29;8(2):2372–2380. doi: 10.18632/oncotarget.13676

Figure 4. MPA decreases the size of recurrent cervical cancer by inhibiting proliferation.

Figure 4

(A) MPA does not decrease multiplicity of recurrent cervical cancer. The number of recurrent cervical cancer per mouse is shown in box plot. Outliers are represented by dots. Control, n = 5; recurrence (rec.) therapy, n = 6. (B) MPA decreases total invasion area. Total invasion area per mouse is shown in box plot. *P = 0.04 (n = 5 for control; n = 6 for recurrence therapy). (C) MPA decreases the size of largest cancer. Largest cancer size per mouse is shown in box plot. *P = 0.03 (n = 5 for control; n = 6 for recurrence therapy). (D) MPA decreases cell proliferation in recurrent cervical cancer. Cervical cancer sections were stained for BrdU (green). Nuclei are shown in blue. Dotted lines separate cancer (cc) from stroma (st). Scale bar, 50 μm. (E) Quantification of results shown in D. is shown as mean ± S.E.M. (n = 3). *P = 0.05. (F) MPA does not influence apoptosis of cancer cells. Cervical cancer sections were subjected to TUNEL assay. TUNEL+ cells are shown in green (see white arrows). Nuclei are shown in blue. Scale bar, 50 μm. (G) Quantification of results shown in F. is shown as mean ± S.E.M. (n = 3).