Table 1. Summary of worst neoplastic diseases in the lower reproductive tract of K14E6/K14E7 mice*.
| Group | Group size,n | No disease | Dysplasia only | Cancer & dysplasia | Cancer incidence,% | Multiplicity (Mean ± S.E.M) | ||
|---|---|---|---|---|---|---|---|---|
| CIN1(VaIN1) | CIN2(VaIN2) | CIN3(VaIN3) | ||||||
| Primary | 7 | 0 (0) | 0 (1) | 0 (4) | 0 (1) | 7 (1) | 100 (14.3) | 1.7±0.2(0.1±0.1) |
| Therapy | 6 | 6 (6) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| De Novo | 16 | 4 (6) | 1 (2) | 5 (4) | 2 (1) | 4 (3) | 25 (18.8) | 0.8±0.4(0.3±0.1) |
| Recurrence (+E2) | 6 | 0 (0) | 0 (1) | 0 (0) | 0 (1) | 6 (4) | 100 (66.7) | 3.0±0.7(2.0±0.9) |
| Recurrence (−E2) | 6 | 0 (1) | 0 (1) | 0 (0) | 0 (0) | 6 (4) | 100 (66.7) | 3.0±0.4(1.3±0.5) |
| Prevention | 7 | 0 (1) | 0 (2) | 0 (2) | 0 (0) | 7 (2) | 100 (28.6) | 2.1±0.3(0.3±0.5) |
| Recurrence therapy | 7# | 0 (1) | 0 (0) | 0 (0) | 0 (1) | 7 (5) | 100 (71.4) | 3.1±0.7(0.9±0.3) |
| Control | 5 | 0 (1) | 0 (0) | 0 (1) | 0 (0) | 5 (3) | 100 (60.0) | 3.2±0.5(1.2±0.6) |
*
Mice were scored histopathologically for the worst disease present in the cervix or, in parentheses, the vagina of each mouse. CIN, cervical intraepithelial neoplasia; VaIN, vaginal intraepithelial neoplasia. P < 0.01 compared to the other groups. #One mouse did not have mucinified cervical epithelium, suggesting that MPA treatment did not work in that mouse. This mouse was excluded from statistical analyses.