Table 2. Comparison of demographics, creatinine, UA, UA/Cr ratio and ocular parameters in subjects with PACG, stratified according to severity.
| Mild PACG, n= 286 | Moderate PACG, n = 198 | Severe PACG, n= 402 | P value | |
|---|---|---|---|---|
| Age, years | 62.79 ± 10.57 | 63.77 ± 10.87 | 63.14 ± 10.61 | 0.605 |
| Female, N (%) | 186 (65.03) | 144 (73.73) | 254 (63.18) | 0.063 |
| SBP (mm Hg) | 131.40 ± 14.82 | 130.20 ± 13.37 | 131.01 ± 14.60 | 0.671 |
| DBP (mm Hg) | 76.39 ± 8.39 | 76.54 ± 7.95 | 76.18 ± 9.62 | 0.891 |
| BMI, Kg/m2 | 23.19 ± 3.30 | 22.45 ± 2.92 | 22.79 ± 4.08 | 0.285 |
| IOP (mm Hg) | 28.80 ± 10.55 | 30.49 ± 11.46 | 36.78 ± 13.11 | < 0.001a,c |
| VCDR | 0.46 ± 0.17 | 0.59 ± 0.20 | 0.81 ± 0.20 | < 0.001a,b,c |
| CCT (mm) | 547.52 ± 55.21 | 537.66 ± 43.11 | 543.91 ± 50.66 | 0.201 |
| ACD (mm) | 1.80 ± 0.46 | 1.85 ± 0.44 | 1.85 ± 0.45 | 0.341 |
| AL (mm) | 22.16 ± 1.17 | 22.29 ± 0.94 | 22.55 ± 1.43 | 0.001a,c |
| MD (dB) | 3.85 ± 1.83 | 9.20 ± 2.15 | 21.65 ± 4.71 | < 0.001a,b,c |
| MS (dB) | 20.52 ± 7.77 | 17.83 ± 2.79 | 5.56 ± 4.77 | < 0.001a,b,c |
| Creatinine (umol/l) | ||||
| Total | 71.53 ± 20.13 | 68.70 ± 16.18 | 68.53 ± 16.22 | 0.065a |
| Male | 85.22 ± 21.10 | 82.92 ± 13.64 | 76.29 ± 12.51 | < 0.001a,b |
| Female | 64.18 ± 15.18 | 63.50 ± 13.75 | 63.96 ± 16.44 | 0.921 |
| UA (mmol/l) | ||||
| Total | 0.297 ± 0.090 | 0.282 ± 0.080 | 0.281 ± 0.074 | 0.032a,b |
| Male | 0.342 ± 0.085 | 0.322 ± 0.058 | 0.317 ± 0.079 | 0.040a |
| Female | 0.273 ± 0.083 | 0.267 ± 0.083 | 0.258 ± 0.061 | 0.049a |
| UA/Cr ratio | ||||
| Total | 4.25 ± 1.21 | 4.23 ± 1.29 | 4.22 ± 1.14 | 0.948 |
| Male | 4.15 ± 1.14 | 3.97 ± 0.89 | 4.24 ± 1.23 | 0.332 |
| Female | 4.31 ± 1.25 | 4.33 ± 1.40 | 4.18 ± 1.09 | 0.384 |
Abbreviations: UA: uric acid, SBP: systolic blood pressure, DBP: diastolic blood pressure, BMI: body mass index, IOP: intraocular pressure, VCDR: vertical cup-disc ratio, CCT: central corneal thickness, AL: axial length, ACD: anterior chamber depth, MD: visual fields mean deviation, MS: visual fields mean sensitivity, PACG: primary angle closure glaucoma. Data are expressed as mean ± standard deviation (SD). Chi-square test and One-way ANOVA was used.
aP < 0.05 for the difference between Mild PACG and Severe PACG (1-way ANOVA with the LSD post hoc test).
bP < 0.05 for the difference between Mild PACG and Moderate PACG (1-way ANOVA with the LSD post hoc test).
cP < 0.05 for the difference between Moderate PACG and Severe PACG (1-way ANOVA with the LSD post hoc test).