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. 2016 Nov 25;8(2):2971–2983. doi: 10.18632/oncotarget.13579

Figure 3. TNK2 is required for mammosphere formation.

Figure 3

Mammosphere assays A. and 3D matrigel assays B. of shTNK2/shCTRL HCC1395 cells with or without doxycycline induction. C. Synergistic effect of knocking down TNK2 with doxorubicin treatment. Doxycycline was used to induce shTNK2 expression. Induced or uninduced cells were treated with different doses of doxorubicin (as indicated). D. Western blot analysis to examine cleaved PARP and Caspase 8 in shCTRL and shTNK2 cells treated with doxorubicin and with or without doxycycline induction of shRNA. β-Actin serves as a loading control.