Table 1. Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in urinary bladder urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival		Metastasis-free Survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	216	41	0.4446	-	-	-	60	0.2720	-	-	-
	Female	79	11		-	-	-	16		-	-	-
Age (years)	< 65	121	17	0.1136	-	-	-	31	0.6875	-	-	-
	≥ 65	174	35		-	-	-	45		-	-	-
Primary tumor (T)	Ta	84	1	< 0.0001*	1	-	< 0.001*	4	< 0.0001*	1	-	0.004*
	T1	88	9		5.554	0.604–51.101		23		4.513	1.311–15.537
	T2-T4	123	42		20.442	2.330–179.356		49		6.288	1.835–21.548
Nodal metastasis	Negative (N0)	266	41	0.0002*	1	-	0.217	61	< 0.0001*	1	-	0.025*
	Positive (N1–N2)	29	11		1.552	0.772–3.119		15		2.003	1.091-3.678
Histological	grade	Low grade	56	2	0.0013*	1	-	0.774	5	0.0007*	1	-	0.519
	High grade	239	50		1.249	0.273–5.722		71		1.403	0.502–3.927
Vascular invasion	Absent	246	37	0.0024*	1	-	0.029*	54	0.0001*	1	-	0.217
	Present	49	15		2.257	1.089–4.695		22		1.477	0.795–2.747
Perineural invasion	Absent	275	44	0.0001*	1	-	0.004*	66	0.0007*	1	-	0.031*
	Present	20	8		3.748	1.518–9.256		10		2.352	1.081–5.115
Mitotic rate (per 10 high power fields)	< 10	139	12	< 0.0001*	1	-	0.010*	23	< 0.0001*	1	-	0.009*
	> = 10	156	40		2.398	1.230–4.677		53		1.978	1.187–3.297
DPP4 expression	Low	147	11	< 0.0001*	1	-	< 0.001*	17	< 0.0001*	1	-	< 0.001*
	High	148	41		3.562	1.763–7.196		59		3.530	2.016–6.182

* Statistically significant.