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. 2016 Dec 7;8(2):2995–3008. doi: 10.18632/oncotarget.13820

Table 1. Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in urinary bladder urothelial carcinoma.

Parameter Category Case No. Disease-specific Survival Metastasis-free Survival
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
No. of event p-value R.R. 95% C.I. p-value No. of event p-value R.R. 95% C.I. p-value
Gender Male 216 41 0.4446 - - - 60 0.2720 - - -
Female 79 11 - - - 16 - - -
Age (years) < 65 121 17 0.1136 - - - 31 0.6875 - - -
≥ 65 174 35 - - - 45 - - -
Primary tumor (T) Ta 84 1 < 0.0001* 1 - < 0.001* 4 < 0.0001* 1 - 0.004*
T1 88 9 5.554 0.604–51.101 23 4.513 1.311–15.537
T2-T4 123 42 20.442 2.330–179.356 49 6.288 1.835–21.548
Nodal metastasis Negative (N0) 266 41 0.0002* 1 - 0.217 61 < 0.0001* 1 - 0.025*
Positive (N1–N2) 29 11 1.552 0.772–3.119 15 2.003 1.091-3.678
Histological grade Low grade 56 2 0.0013* 1 - 0.774 5 0.0007* 1 - 0.519
High grade 239 50 1.249 0.273–5.722 71 1.403 0.502–3.927
Vascular invasion Absent 246 37 0.0024* 1 - 0.029* 54 0.0001* 1 - 0.217
Present 49 15 2.257 1.089–4.695 22 1.477 0.795–2.747
Perineural invasion Absent 275 44 0.0001* 1 - 0.004* 66 0.0007* 1 - 0.031*
Present 20 8 3.748 1.518–9.256 10 2.352 1.081–5.115
Mitotic rate (per 10 high power fields) < 10 139 12 < 0.0001* 1 - 0.010* 23 < 0.0001* 1 - 0.009*
> = 10 156 40 2.398 1.230–4.677 53 1.978 1.187–3.297
DPP4 expression Low 147 11 < 0.0001* 1 - < 0.001* 17 < 0.0001* 1 - < 0.001*
High 148 41 3.562 1.763–7.196 59 3.530 2.016–6.182

* Statistically significant.