Table 2. Univariate log-rank and multivariate analyses for disease-specific and metastasis-free survivals in upper urinary tract urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival		Metastasis-free Survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	158	28	0.8286	-	-	-	32	0.7904	-	-	-
	Female	182	33		-	-	-	38		-	-	-
Age (years)	< 65	138	26	0.9943	-	-	-	30	0.8470	-	-	-
	≥ 65	202	35		-	-	-	40		-	-	-
Tumor side	Right	177	34	0.7366	-	-	-	38	0.3074	-	-	-
	Left	154	26		-	-	-	32		-	-	-
	Bilateral	9	1		-	-	-	0		-	-	-
Tumor location	Renal pelvis	141	24	0.0079*	1	-	0.873	31	0.0659	-	-	-
	Ureter	150	22		0.770	0.413–1.435		25		-	-	-
	Renal pelvis & ureter	49	15		1.331	0.369–4.803		14		-	-	-
Multifocality	Single	273	48	0.0026*	1	-	0.012*	52	0.0127*	1	-	0.005*
	Multifocal	62	18		2.658	1.241–5.692		18		2.201	1.288–6.003
Primary tumor (T)	Ta	89	2	< 0.0001*	1	-	0.040*	4	< 0.0001*	1	-	0.275
	T1	92	9		3.562	0.757–16.746		15		2.140	0.143–2.384
	T2-T4	159	50		4.004	0.869–18.459		51		3.938	0.047–3.136
Nodal metastasis	Negative (N0)	312	42	< 0.0001*	1	-	< 0.001*	55	< 0.0001*	1	-	0.001*
	Positive (N1-N2)	28	19		4.862	2.622–9.017		15		2.711	1.465–5.016
Histological grade	Low grade	56	4	0.0215*	1	-	0.073	3	0.0027*	1	-	0.034*
	High grade	284	57		2.740	0.912–8.233		67		3.636	1.105–11.965
Vascular invasion	Absent	234	24	< 0.0001*	1	-	0.316	26	< 0.0001*	1	-	0.010*
	Present	106	37		1.362	0.745–2.493		44		2.225	1.214–4.075
Perineural invasion	Absent	321	50	< 0.0001*	1	-	< 0.001*	61	< 0.0001*	1	-	0.009*
	Present	19	11		4.049	1.924–8.521		9		2.705	1.282–5.706
Mitotic rate (per 10 high power fields)		< 10	173	27	0.167	-	-	-	30	0.0823	-	-	-
	> = 10	167	34		-	-	-	40		-	-	-
DPP4 expression	Low	170	11	< 0.0001*	1	-	0.028*	12	< 0.0001*	1	-	0.031*
	High	170	50		2.383	1.099–5.167		58		2.048	1.068–3.926

* Statistically significant.