Table 4. The list of 34 contributive genes common to the 4 ARB drugs.
| Gene Symbol | Description | Regulation |
|---|---|---|
| ABHD2 | Abhydrolase Domain Containing 2 | Up |
| APOBEC1 | Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 | Up |
| BCL2L14 | Bcl2-Like 14 (Apoptosis Facilitator) | Up |
| C3orf52 | Chromosome 3 Open Reading Frame 52 | Up |
| CD44 | Cd44 Molecule (Indian Blood Group) | Up |
| CD55 | Cd55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group) | Up |
| CKAP4 | Cytoskeleton-Associated Protein 4 | Up |
| CTSE | Cathepsin E | Up |
| DSG3 | Desmoglein 3 | Up |
| DUSP4 | Dual Specificity Phosphatase 4 | Up |
| EPS8L1 | Eps8-Like 1 | Up |
| HGD | Homogentisate 1,2-Dioxygenase | Up |
| HOXB3 | Homeobox B3 | Up |
| HOXB5 | Homeobox B5 | Up |
| HOXB6 | Homeobox B6 | Up |
| HOXB7 | Homeobox B7 | Up |
| HOXB9 | Homeobox B9 | Up |
| IL33 | Interleukin 33 | Up |
| KIAA1199 | Cell Migration Inducing Protein, Hyaluronan Binding [CEMIP] | Up |
| KRT6B | Keratin 6B | Up |
| LYZ | Lysozyme | Up |
| MAP3K5 | Mitogen-Activated Protein Kinase Kinase Kinase 5 | Up |
| ME1 | Malic Enzyme 1, NADP(+)-Dependent, Cytosolic | Up |
| MSX2 | Msh Homeobox 2 | Up |
| MUC2 | Mucin 2, Oligomeric Mucus/Gel-Forming | Up |
| NAAA | N-Acylethanolamine Acid Amidase | Down |
| RBMS1 | RNA Binding Motif, Single Stranded Interacting Protein 1 | Down |
| REEP1 | Receptor Accessory Protein 1 | Down |
| RGNEF | Rho Guanine Nucleotide Exchange Factor (GEF) 28 [ARHGEF28] | Up |
| SCRN1 | Secernin 1 | Down |
| TFF1 | Trefoil Factor 1 | Up |
| TFF3 | Trefoil Factor 3 (Intestinal) | Up |
| TRIM16 | Tripartite Motif Containing 16 | Up |
| ZBTB10 | Zinc Finger And Btb Domain Containing 10 | Down |
The signed ranks of signature genes in the reference profiles of 4 ARB drugs were analyzed in conjunction with their regulation directions. Genes that make a strong and consistent contribution to the inverse connection scores are selected for each of the 4 ARB drugs. The 4 lists of contributive genes were overlapped and the common set of 34 is itemized here. Their directions of regulation in the signature are indicated in the last column.