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. 2016 Dec 2;8(2):3396–3411. doi: 10.18632/oncotarget.13773

Figure 2. GSK126 inhibits growth of multiple myeloma cells.

Figure 2

A. MM cells were incubated with increasing concentrations of GSK126 for 72 h. The cell viability was measured by MTS assay. Dose-response curves are shown. B. Clonogenicity of MM cells were evaluated with drug-free soft agar assay in the indicated lines of MM cells after 24 h of pre-treatment with the escalating concentrations of GSK126. Curves are plotted with mean ± SEM. C. The colony-formation ability of RPMI8226 and LP1 cells that were transfected with constructs empty vector, EZH2-WT, or EZH2-H694A was measured in soft-agar assay, and the overexpression of wild type and mutant EZH2 was examined by immunoblotting. **, P < 0.01; ***, P < 0.0001, one-way ANOVA with post hoc intergroup comparison by the Tukey's test.