Table 4. List of pairs of homologous enzymes of different families and the results of SVM functional family assignment.
| Enzyme E1 (Swiss-Prot accession number) | EC class (F1) | Enzyme E2 (Swiss-Prot accession number) | EC class (F2) | Sequence similarity (BLAST E-value) | SVM functional family assignment | Assignment status |
|---|---|---|---|---|---|---|
| Glycolateoxidase (P05414) | EC 1.1 | IPP isomerase (Q8PW37) | EC 5.3 | 3.00E−07 | E1->F1;E2->F2 | + |
| Creatine amidinohydrolase (P38488) | EC 3.5 | Prolinedipeptidase (O58885) | EC 3.4 | 3.00E−15 | E1->F1;E2->F2 | + |
| Cystathionine gamma-synthase (P38675) | EC 2.5 | Methionine gamma-lyase (P13254) | EC 4.4 | 2.00E−15 | E1->W;E2->F2 | − |
| Exocellobiohydrolase 1 (P38676) | EC 3.2 | Cystathionine gamma-lyase (Q8VCN5) | EC 4.4 | 1.00E−12 | E1->W;E2->F2 | − |
| Maleylacetoacetate isomerase (P57109) | EC 5.2 | Glutathione S-transferase zeta class (P57108) | EC 2.5 | 1.00E−51 | E1->F1;E2->F2 | + |
| Tyrosine-protein kinase FRK (P42685) | EC 2.7 | Intestinalguanylate cyclase (P70106) | EC 4.6 | 2.60E−12 | E1->F1;E2->F1 | − |
| Glutamate-1-semialdehyde aminotransferase (Q06774) | EC 5.4 | 4-aminobutyrate aminotransferase (P22256) | EC 2.6 | 5.70E−32 | E1->F1;E2->F2 | + |
| Exodeoxyribonuclease (P37454) | EC 3.1 | DNA- (apurinic or apyrimidinic site) lyase (P43138) | EC 4.2 | 1.60E−96 | E1->F1;E2->F2 | + |
E1-> F1 or E2 -> F2 indicates that enzyme E1 or E2 is assigned into family F1 and F2 respectively. E1-> W or E2 -> W indicates that enzyme E1 or E2 is assigned into a wrong family respectively. The symbol + or − represents the cases that SVM is able or unable to distinguish the two enzymes and exclusively assign them into the respective family.