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. 2016 Oct 8;8(2):3711–3723. doi: 10.18632/oncotarget.12533

Figure 1. Schematic view of the two forms of FGL2.

Figure 1

A. Membrane bound FGL2 (mFGL2) is a type II transmembrance glycoprotein expressed by macrophages or endothelial cells. The N-terminal linear coiled-coil domain (Serine 89) of mFGL2 is responsible for its prothrombinase activity, while function of C-terminal FRED domain remains unclarified. B. Soluble FGL2 (sFGL2) lacking the N-terminal hydrophobic sequence is mainly secreted by CD4+CD25+Tregs. sFGL2 expressed by CD8+CD45RClow T cells, CD8αα+ suppressive intraepithelial lymphocytes (IELs), and CD3+CD4-CD8- double negative T cells (DNTs) also accounts for a small proportion of sFGL2 origin. sFGL2 in its natural state exists as an oligomer consisting of 4 monomers.