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In study 3, ex vivo incubation of human internal mammary arteries (from 10 patients) with atorvastatin induced a significant increase of vascular tetrahydrobiopterin (BH4; A) and total biopterins (tBio; B) compared with control. Atorvastatin also significantly increased GCH1 mRNA (relative to GAPDH) in these vessels (C). Values are expressed as median (25th to 75th percentile). − Indicates no atorvastatin; +, atorvastatin 5 μmol/L. *P<0.05, **P<0.01 vs control (no atorvastatin).
