Table 1. Results from ex vivo biodistribution of saline solutions containing 52Mn administered via intravenous injection or inhalation.
| Uptake of 52Mn (%ID/g) | t-test (p) | ||||
|---|---|---|---|---|---|
| Intravenous | Inhalation | ||||
| 1 h | 1 d | 1 h | 1 d | 1 d | |
| Blood | 1.3 ± 0.2 | 0.10±0.02 | 0.019±0.008 | 0.007±0.003 | 0.0011 |
| Lung | 11 ± 3 | 4.5±0.4 | 16±5 | 18±4 | 0.026 |
| Liver | 20 ± 2 | 12±1 | 0.39±0.09 | 0.7±0.2 | 0.00013 |
| Spleen | 9 ± 3 | 3.3±0.3 | 0.07±0.03 | 0.12±0.05 | 0.00025 |
| Kidney | 18 ± 2 | 17±2 | 0.31±0.09 | 2.0±0.7 | 0.00012 |
| Muscle | 1.4 ± 0.2 | 1.13±0.09 | 0.14±0.05 | 0.04±0.03 | 0.000028 |
| Heart | 10 ± 2 | 2.9±0.4 | 0.3±0.1 | 0.23±0.08 | 0.020 |
| Brain | 0.8±0.1 | 0.9±0.1 | 0.09±0.07 | 0.3±0.4 | 0.00034 |
| Bone | 2.90±0.08 | 2.6±0.3 | 0.1±0.2 | 0.11±0.03 | 0.14 |
| Thyroid | 3±1 | 2.2±0.7 | 6±4 | 6±3 | 0.00026 |
| Pancreas | 9±1 | 10±3 | 0.25±0.02 | 0.8±0.4 | 0.17 |
| Stomach | 2.1±0.6 | 1.4±0.5 | 21±6 | 2±1 | 0.0073 |
| Whole Intestine | 4.2±0.6 | 1.51±0.06 | 20±3 | 3.6±0.7 | 0.00029 |
| Salivary Gland | 6.7±0.8 | 6.8±0.6 | 1.2±0.2 | 0.5±0.2 | 0.29 |
| Fat | 0.58±0.09 | 0.4±0.2 | 0.2±0.2 | 0.004±0.001 | 0.031 |
| Thymus | 1.3±0.2 | 0.9±0.1 | 1±1 | 0.1±0.1 | 0.000074 |
The timepoints shown represent time after administration of the dose. Sample sizes for each timepoint were n = 4 mice for injection and n = 3 for inhalation. Uncertainties: one absolute standard deviation in units of %ID/g (i.e., percentage does not imply relative sample standard deviation). All values for uncertainty were rounded to one significant digit, and the mean value was rounded to a matching number of decimal places. Results for the p-values from Student’s t-test with Welch’s correction are shown rounded (up or down) to two significant digits. The numerical results in this table have been plotted in Fig 1.