Table 2.
Comparison of miRNA expression by adenoma type
| miRNA |
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean Level of Expression | Adenomatous vs SSP | Adenomatous vs Hyperplastic | Hyperplastic vs SSP | |||||||
|
| ||||||||||
| Normal | Adenomatous | SSP | Hyperplastic | FC | Adjusted p value | FC | Adjusted p value | FC | Adjusted p value | |
| hsa-let-7a-5p | 166.36 | 178.99 | 98.54 | 87.35 | 1.82 | 0.03 | 2.05 | 0.005 | 1.13 | 0.74 |
| hsa-let-7b-5p | 223.1 | 224.82 | 164.32 | 134.83 | 1.37 | 0.18 | 1.67 | 0.01 | 1.22 | 0.40 |
| hsa-let-7c | 54.52 | 51.77 | 40.45 | 32.01 | 1.28 | 0.39 | 1.62 | 0.02 | 1.26 | 0.41 |
| hsa-let-7d-5p | 24.64 | 28.05 | 14.61 | 13.73 | 1.92 | 0.04 | 2.04 | 0.006 | 1.06 | NA |
| hsa-let-7f-5p | 84.3 | 95.38 | 47.46 | 42.8 | 2.01 | 0.02 | 2.23 | 0.003 | 1.11 | 0.87 |
| hsa-let-7g-5p | 34.46 | 37.86 | 18.5 | 14.26 | 2.05 | 0.04 | 2.66 | 0.005 | 1.30 | NA |
| hsa-miR-103a-3p | 35.15 | 44.69 | 22.15 | 23.35 | 2.02 | 0.03 | 1.91 | 0.005 | 0.95 | NA |
| hsa-miR-107 | 22.23 | 26.82 | 12.98 | 13.21 | 2.07 | 0.02 | 2.03 | 0.005 | 0.98 | NA |
| hsa-miR-10a-5p | 17.83 | 23.97 | 13.51 | 8.78 | 1.77 | 0.20 | 2.73 | 0.008 | 1.54 | NA |
| hsa-miR-1225-5p | 3269.87 | 3320.42 | 3587.1 | 4478.36 | 0.93 | 0.18 | 0.74 | 0.04 | 0.80 | 0.35 |
| hsa-miR-1234-3p | 43.95 | 40.34 | 40.03 | 57.69 | 1.01 | 0.88 | 0.70 | 0.03 | 0.69 | 0.07 |
| hsa-miR-1246 | 393.84 | 519.46 | 379.29 | 403.11 | 1.37 | 0.0006 | 1.29 | 0.005 | 0.94 | 0.47 |
| hsa-miR-125b-5p | 32.85 | 8.68 | 18.7 | 11.95 | 0.46 | 0.009 | 0.73 | 0.08 | 1.57 | NA |
| hsa-miR-1323 | 6.47 | 7.01 | 9.51 | 7.93 | 0.74 | 0.009 | 0.88 | 0.43 | 1.20 | NA |
| hsa-miR-141-3p | 21.1 | 31.79 | 12.46 | 11.45 | 2.55 | 0.008 | 2.78 | <0.0001 | 1.09 | NA |
| hsa-miR-145-5p | 185.82 | 55.7 | 102.07 | 105.15 | 0.55 | 0.0008 | 0.53 | 0.0004 | 0.97 | 0.69 |
| hsa-miR-1470 | 4.26 | 3.28 | 4.73 | 5.14 | 0.69 | 0.02 | 0.64 | 0.009 | 0.92 | NA |
| hsa-miR-15b-5p | 17.39 | 22.27 | 8.85 | 7.86 | 2.51 | 0.02 | 2.83 | 0.006 | 1.13 | NA |
| hsa-miR-16-5p | 46.88 | 50.58 | 27.93 | 26.56 | 1.81 | 0.02 | 1.90 | 0.004 | 1.05 | 0.95 |
| hsa-miR-17-5p | 12.09 | 23.68 | 8.29 | 9.42 | 2.86 | 0.004 | 2.51 | 0.003 | 0.88 | NA |
| hsa-miR-192-5p | 99.98 | 96.27 | 49.44 | 43.32 | 1.95 | 0.01 | 2.22 | 0.002 | 1.14 | 0.99 |
| hsa-miR-1973 | 789.22 | 929.03 | 525.84 | 496.47 | 1.77 | 0.0009 | 1.87 | <0.0001 | 1.06 | 0.97 |
| hsa-miR-200a-3p | 15.63 | 23.97 | 7.3 | 5.62 | 3.28 | 0.003 | 4.26 | 0.0006 | 1.30 | NA |
| hsa-miR-200b-3p | 103.56 | 168.92 | 53.91 | 50.18 | 3.13 | 0.0004 | 3.37 | <0.0001 | 1.07 | 0.98 |
| hsa-miR-200c-3p | 95.42 | 153.38 | 61.12 | 61.38 | 2.51 | 0.0002 | 2.50 | <0.0001 | 1.00 | 0.72 |
| hsa-miR-21-5p | 97.57 | 154.87 | 73.59 | 73.37 | 2.10 | 0.009 | 2.11 | 0.005 | 1.00 | 0.86 |
| hsa-miR-222-3p | 7.69 | 9.04 | 12.84 | 12.88 | 0.70 | 0.01 | 0.70 | 0.002 | 1.00 | 0.63 |
| hsa-miR-22-3p | 10.79 | 6.13 | 8.94 | 9.51 | 0.69 | NA | 0.64 | 0.02 | 0.94 | NA |
| hsa-miR-23a-3p | 60.92 | 94.23 | 41.69 | 51.37 | 2.26 | 0.004 | 1.83 | 0.01 | 0.81 | 0.28 |
| hsa-miR-23b-3p | 52.29 | 55.89 | 29.78 | 32.11 | 1.88 | 0.05 | 1.74 | 0.02 | 0.93 | NA |
| hsa-miR-24-3p | 45.68 | 62.08 | 34.39 | 38.8 | 1.81 | 0.002 | 1.60 | 0.006 | 0.89 | 0.30 |
| hsa-miR-25-3p | 7.87 | 12.94 | 5.37 | 5.51 | 2.41 | NA | 2.35 | 0.02 | 0.97 | NA |
| hsa-miR-26a-5p | 70.89 | 74.86 | 41.99 | 38.33 | 1.78 | 0.04 | 1.95 | 0.01 | 1.10 | 0.89 |
| hsa-miR-27a-3p | 14.6 | 27.42 | 9.13 | 10.52 | 3.00 | NA | 2.61 | 0.008 | 0.87 | NA |
| hsa-miR-27b-3p | 18.27 | 23.79 | 9.82 | 8.59 | 2.42 | 0.01 | 2.77 | 0.007 | 1.14 | NA |
| hsa-miR-29a-3p | 31.9 | 51.07 | 23.27 | 23.43 | 2.19 | 0.01 | 2.18 | 0.007 | 0.99 | 0.83 |
| hsa-miR-29b-3p | 5.42 | 8.54 | 3.91 | 3.82 | 2.18 | NA | 2.24 | 0.02 | 1.02 | NA |
| hsa-miR-30d-5p | 24.06 | 23.44 | 15.59 | 15.45 | 1.50 | 0.001 | 1.52 | 0.0008 | 1.01 | 0.94 |
| hsa-miR-3174 | 11.76 | 12.52 | 9.58 | 10.61 | 1.31 | 0.01 | 1.18 | 0.04 | 0.90 | 0.11 |
| hsa-miR-3177-5p | 4.67 | 4.18 | 5.85 | 5.6 | 0.71 | 0.05 | 0.75 | 0.04 | 1.05 | NA |
| hsa-miR-3196 | 1524.08 | 1612.26 | 1831.32 | 2337.48 | 0.88 | 0.10 | 0.69 | 0.01 | 0.78 | 0.20 |
| hsa-miR-320d | 40.15 | 41.42 | 32.7 | 30.94 | 1.27 | 0.03 | 1.34 | 0.01 | 1.06 | 0.62 |
| hsa-miR-330-3p | 4.76 | 4.1 | 6.75 | 7.67 | 0.61 | 0.008 | 0.54 | 0.01 | 0.88 | NA |
| hsa-miR-342-3p | 12.79 | 6.34 | 13.01 | 9.39 | 0.49 | 0.007 | 0.67 | 0.02 | 1.38 | NA |
| hsa-miR-3651 | 21.94 | 42.02 | 16.74 | 15.88 | 2.51 | 0.0003 | 2.65 | 0.0002 | 1.05 | 0.88 |
| hsa-miR-375 | 42.33 | 41.12 | 21.06 | 25.46 | 1.95 | 0.01 | 1.62 | 0.09 | 0.83 | 0.22 |
| hsa-miR-424-3p | 23.54 | 32.36 | 22.69 | 20.18 | 1.43 | 0.0008 | 1.60 | <0.0001 | 1.12 | 0.30 |
| hsa-miR-4284 | 1161.35 | 1465.29 | 753.46 | 836.4 | 1.94 | 0.002 | 1.75 | 0.002 | 0.90 | 0.28 |
| hsa-miR-431-5p | 46.86 | 45.5 | 53.7 | 63.98 | 0.85 | 0.10 | 0.71 | 0.007 | 0.84 | 0.29 |
| hsa-miR-4323 | 11.19 | 8.77 | 9.57 | 14.29 | 0.92 | 0.26 | 0.61 | <0.0001 | 0.67 | 0.00 |
| hsa-miR-4449 | 13.41 | 22.01 | 12.3 | 11.63 | 1.79 | <0.0001 | 1.89 | <0.0001 | 1.06 | 0.27 |
| hsa-miR-4472 | 12.15 | 12.69 | 17.51 | 13.64 | 0.72 | 0.04 | 0.93 | 0.42 | 1.28 | 0.21 |
| hsa-miR-4485 | 1185.77 | 1294.33 | 804.72 | 823.47 | 1.61 | 0.0007 | 1.57 | 0.0008 | 0.98 | 0.83 |
| hsa-miR-4502 | 18.19 | 16.27 | 22.16 | 18.54 | 0.73 | 0.03 | 0.88 | 0.05 | 1.20 | 0.39 |
| hsa-miR-4526 | 4.06 | 3.73 | 5.4 | 4.74 | 0.69 | 0.0002 | 0.79 | 0.07 | 1.14 | NA |
| hsa-miR-4707-3p | 10.78 | 10.06 | 13.23 | 14.44 | 0.76 | 0.02 | 0.70 | 0.02 | 0.92 | 0.97 |
| hsa-miR-4749-3p | 13.45 | 12.67 | 17.38 | 20.56 | 0.73 | 0.003 | 0.62 | 0.002 | 0.85 | 0.47 |
| hsa-miR-4787-3p | 104.13 | 95.09 | 98.92 | 131.05 | 0.96 | 0.82 | 0.73 | 0.03 | 0.75 | 0.17 |
| hsa-miR-492 | 12.4 | 9.51 | 23.08 | 37.84 | 0.41 | <0.0001 | 0.25 | <0.0001 | 0.61 | 0.00 |
| hsa-miR-501-3p | 2.63 | 5.32 | 2.49 | 2.66 | 2.14 | 0.003 | 2.00 | 0.005 | 0.93 | NA |
| hsa-miR-5585-5p | 4.68 | 4.42 | 6.57 | 7.18 | 0.67 | 0.08 | 0.62 | 0.03 | 0.91 | NA |
| hsa-miR-650 | 15.94 | 9.15 | 17.64 | 10.03 | 0.52 | 0.002 | 0.91 | 0.19 | 1.76 | 0.02 |
| hsa-miR-654-5p | 28.25 | 27 | 31.91 | 37.32 | 0.85 | 0.10 | 0.72 | 0.02 | 0.86 | 0.47 |
| hsa-miR-663b | 32.65 | 49.56 | 35.33 | 38.08 | 1.40 | 0.0008 | 1.30 | 0.01 | 0.93 | 0.55 |
| hsa-miR-664a-5p | 9.97 | 11.9 | 5.58 | 2.92 | 2.13 | 0.006 | 4.08 | NA | 1.91 | NA |
| hsa-miR-664b-3p | 18.8 | 21.3 | 15.25 | 11.52 | 1.40 | 0.03 | 1.85 | 0.0002 | 1.32 | 0.10 |
| hsa-miR-664b-5p | 39.56 | 46.98 | 28.48 | 22.07 | 1.65 | 0.001 | 2.13 | <0.0001 | 1.29 | 0.09 |
| hsa-miR-758-5p | 31.78 | 36.59 | 25.83 | 26.61 | 1.42 | 0.0009 | 1.37 | 0.0002 | 0.97 | 0.46 |
| hsa-miR-92a-3p | 32.05 | 53.77 | 20.79 | 19.35 | 2.59 | 0.0004 | 2.78 | <0.0001 | 1.07 | 0.98 |
| hsa-miR-93-5p | 10.54 | 21.32 | 7.62 | 8.25 | 2.80 | 0.006 | 2.59 | 0.006 | 0.92 | NA |