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. Author manuscript; available in PMC: 2018 Mar 17.
Published in final edited form as: ACS Chem Biol. 2017 Jan 20;12(3):682–691. doi: 10.1021/acschembio.6b01071

Figure 3. Proposed biosynthetic pathway for the formation of the MTX motif of ManLAM in M. tuberculosis.

Figure 3

The proposed catalytic steps leading to the synthesis of the MTX motif and its transfer onto the mannoside caps of M. tuberculosis ManLAM are represented. The identity of the translocase involved in the translocation of DP-MTX from the cytoplasmic to the periplasmic side of the inner membrane and the precise nature of the nucleotide-MTX donor used by MtxS in the formation of DP-MTX are not known.