Dose-dependent inhibition of cell proliferation by calcitriol (1,25(OH)2D3) (triangle) and gemini analogs, BXL0124 (square) and BXL0097 (circle) in (A) MCF10DCIS cells and (B) MCF-7 cells. The calculated IC50 for the inhibitory effect in MCF10DCIS of 1,25(OH)2D3, BXL0097 and BXL0124 are 2.65 nM, 0.56 nM and 0.23 nM, respectively and in MCF-7 24 nM, 0.36 nM and 0.19 nM, respectively.