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. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2016 Sep 17;173:69–74. doi: 10.1016/j.jsbmb.2016.09.015

Crystal structure of zVDR LBD-BXL0124 complex. (A) Overlay of BXL0124 (orange) and BXL0097 (grey) within VDR LBPs. (B) Enhanced visualization of the interactions formed by the C19 methylene group of BXL0124. (C) Details of interactions between LBP and BXL0124. Hydrophobic and van der Waals interactions (grey), and polar contacts (red) are displayed at 4.0 Ȧ cut-off (dotted lines). Amino acids with major contribution are named. Oxygen and fluorine atoms are shown in red and cyan, respectively.

Crystal structure of zVDR LBD-BXL0124 complex. (A) Overlay of BXL0124 (orange) and BXL0097 (grey) within VDR LBPs. (B) Enhanced visualization of the interactions formed by the C19 methylene group of BXL0124. (C) Details of interactions between LBP and BXL0124. Hydrophobic and van der Waals interactions (grey), and polar contacts (red) are displayed at 4.0 Ȧ cut-off (dotted lines). Amino acids with major contribution are named. Oxygen and fluorine atoms are shown in red and cyan, respectively.