| Based on the available data, the consensus panel determined that OTC PPIs are unlikely to mask the symptoms of esophageal or gastric cancer if used as directed. |
| OTC PPIs are not likely to affect micronutrient absorption or bone mineral density or cause community-acquired pneumonia, Clostridium difficile infection, or cardiovascular adverse events. |
| However, using an OTC PPI may increase the risks for infectious diarrhea, certain idiosyncratic reactions, and cirrhosis-related spontaneous bacterial peritonitis. |
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