Fig. 1.

Murine and human tissues express different OGN variants in distinct cardiac diseases. a Western blot analysis for OGN revealed a small variant (34 kDa) in murine myocardial infarction, whereas in murine viral myocarditis, a large variant (72 kDa) was present (n ≥ 4). b Western blot analysis of cardiac tissues of mice 7 days after viral exposure was compared with healthy controls and quantified. Viral infection led to increased expression of a 70–72 kDa OGN variant compared with healthy controls (sham n = 3, VM n = 5, *p < 0.05). c Differential expression of the main OGN variants in various healthy murine tissues. d Western blot analysis for OGN in human ischemic myocardial tissue showing increased expression of the large (72 kDa) and the small (34 kDa) OGN variants relative to those in the control cardiac tissue. e Human buffy coat revealed a similar presence of the OGN variants with high abundance of the 72-kDa variant, which was barely detectable in human splenic tissues