Poxviruses encode divergent number of motifs; the motif-containing proteins (McPs) profile of closely related viruses are correlated. The number of motif-containing proteins (i.e., protein containing at least one instance of the query motif) were counted and normalized (percentage) to total number of proteins encoded by a virus, Table 1, S3. a Box and whisker plot shows 1st, 2nd, 3rd quantiles (Q1, Q2 and Q3 respectively) of numbers of McPs, whiskers at 1.5 IQR (interquartile range) (Q3 + 1.5 IQR); b the average and maximum numbers of McPs, the error bars are based on standard deviation values; c Spearman correlation coefficient values and scatterplots (using STASTICA Data Miner; StatSoft, USA) of the number of McPs encoded by each virus. VacV: Vaccinia virus WR, VarV: Variola virus, MPxV: Monkeypox virus, YMTV: Yaba monkey tumor virus, FPxV: Fowlpox virus, CPxV: Canarypox virus, Orf V: Orf virus, CPxV: Cowpox virus, CmPxV: Camelpox virus M-96, MV: Myxoma virus, and NileCV: Nile crocodilepox virus