Table 2.
Comparison of CTNNB1 mutation in subtypes of hepatocellular carcinoma
| References | CTNNB1 mutant samples | Mutation type | Amino acid | Region | ||
|---|---|---|---|---|---|---|
| HCV | HBV | NV | ||||
| Hirotsu et al. [40] | 2/5 (40%) | 0/1 (0%) | 0/3 (0%) | Missense | Gly34, His36 | Japan |
| Kitao et al. [43] | 12/55 (21.8%) | 4/34 (11.8%) | 11/44 (25%) | NA | NA | Japan |
| Ding et al. [44] | NA | 12/110 (10.9%) | 3/46 (6.5%) | Missense | Asp32, Gly34, Ser37, Thr41, Ser45 | China |
| Tornesello et al. [45] | 10/57 (17.5%) | 0/10 (0%) | NA | Missense | Asp32, Ser33, Gly34 Ile35, Ser37, Ser45 | Southern Italy |
| Kan et al. [42] | NA | 12/81 (14.8%) | NA | Missense | Asp32, Ser33, Gly34 Ile35, Ser37, Thr41, Ser45 | China |
| Guichard et al. [47] | 8/24 (33.3%) | 4/35 (11.4%) | 30/80 (37.5%) | Missense Insertion Deletion |
Asp32, Ser33, Ser37, Thr41,Thr42, Ser45 | France |
| Li et al. [49] | 14/45 (31.1%) | 6/52 (11.5%) | 9/44 (20.5%) | Missense Deletion |
Asp32, Ser33, Gly34, His36, Ser37, Thr41, Ser45, Asn387 | USA, Netherlands, China |
| Bengochea et al. [38] | 8/20 (40%) | 3/18 (16.7%) | 5/24 (20.8%) | Missense Insertion |
Asp32, Ser33, Ser37, Thr41 Ser45 | Thailand, France |
| Kim et al. [52] | 0/4 (0%) | 0/21 (0%) | 1/14 (7.1%) | Missense | Ser33 | China |
| Park et al. [56] | 0/6 (0%) | 13/78 (16.7%) | NA | Missense Deletion |
Asp32, Ser33, Gly34 Ile35, His36, Ser37, Thr41, Ser45 | Korea |
| Edamoto et al. [59] | 16/51 (31.4%) | 5/26 (19.2%) | 3/23 (13%) | Missense | Asp32, Ser33, His36, Ser37, Thr41, Ser45 | Japan, Switzerland |
| Wong et al. [61] | 0/2 (0%) | 5/48 (10.4%) | 2/10 (20%) | Missense Deletion |
Asp32, Ser33, Gly34 Ile35, Ser37, Thr41, Ser45 | China |
| Hsu et al. [66] | 23/92 (25%) | 30/323 (9.3%) | 4/19 (21.1%) | Missense Deletion |
Asp32, Gly34, Thr41, Ser45 |
Taiwan |
| Huang et al. [68] | 9/22 (41%) | NA | NA | Missense | Asp32, Ser33, Ser37, Thr41, Ser45 |
Japan, Switzerland |
| Legoix et al. [69] | 7/30 (23.3%) | 5/26 (19.2%) | 13/64 (20.3%) | Missense Deletion |
Asp32, Ser33, Gly34, Ser37, Thr41, Ser45 | France |
| Terris et al. [70] | 2/7 (28.6) | 3/14 (21.4) | 9/52 (17.3) | Missense Deletion |
Asp32, Ser33, Gly34, Ser37, Ser45 | France |
| Kondo et al. [71] | 7/22 (31.8%) | 1/8 (12.5%) | 1/9 (11.1%) | Missense Deletion |
Asp32, Ser33, Gly34, Ile35, His36, Ser37, Thr41, Ser45 | Japan |
| Total | 118/442 (26.7%) | 103/885 (11.6%) | 91/432 (21.1%) | |||
HBV hepatitis B virus, HCV hepatitis C virus, NA not analyzed, NV not viral