Table 3.
Time trends of mortality in patients with non-functioning pituitary adenoma in Sweden followed between 1997 and 2014
| Outcome | Expected no. of deaths | Observed no. of deaths | Standardized mortality ratio (95 % CI) | P value |
|---|---|---|---|---|
| Overall mortality | ||||
| Mena | 293.4 | 320 | 1.09 (0.97–1.22) | 0.13 |
| Womena | 168.1 | 230 | 1.37 (1.20–1.55) | <0.0001 |
| Time trends depending on year of diagnosis | ||||
| Overall | ||||
| 1997–2001 | 187.8 | 217 | 1.16 (1.01–1.32) | 0.040 |
| 2002–2006 | 167.7 | 213 | 1.27 (1.11–1.45) | 0.0009 |
| 2007–2011 | 106.0 | 120 | 1.13 (0.94–1.35) | 0.19 |
| Men | ||||
| 1997–2001 | 114.1 | 117 | 1.03 (0.85–1.23) | 0.81 |
| 2002–2006 | 107.7 | 123 | 1.14 (0.95–1.36) | 0.16 |
| 2007–2011 | 71.6 | 80 | 1.12 (0.89–1.39) | 0.35 |
| Women | ||||
| 1997–2001 | 73.7 | 100 | 1.36 (1.10–1.65) | 0.004 |
| 2002–2006 | 60.0 | 90 | 1.50 (1.21–1.84) | 0.0004 |
| 2007–2011 | 34.4 | 40 | 1.16 (0.83–1.58) | 0.38 |
| Patients treated with surgery | ||||
| 1997–2001 | 86.5 | 100 | 1.16 (0.94–1.41) | 0.17 |
| 2002–2006 | 85.1 | 102 | 1.20 (0.98–1.45) | 0.082 |
| 2007–2011 | 42.9 | 42 | 0.98 (0.71–1.32) | 0.97 |
| Patients treated with radiotherapy | ||||
| 1997–2001 | 3.1 | 13 | 4.19 (2.23–7.16) | <0.0001 |
| 2002–2006 | 5.8 | 16 | 2.76 (1.58–4.48) | 0.007 |
| 2007–2011 | 2.5 | 13 | 5.22 (2.78–8.93) | <0.0001 |
a Standardized mortality ratio significantly (P = 0.011) different between men and women