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. 2016 Nov 24;42(3):876–890. doi: 10.1007/s11064-016-2110-y

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Changes in the protein levels of various sirtuins in the aged rat brain. The influence of physiological brain aging on the protein levels of various sirtuins in the rodent model. 24 months old rats are compared to adults (3 months old). Predominant cellular localizations of sirtuin proteins are marked in hippocampus and cerebral cortex. ^±No change. *Increased protein but lower activity [71]. ¹Change observed only in the occipital but not frontal or temporal lobes of the cerebral cortex. ²Only in frontal but not occipital or temporal lobe