Table 2.
Anthropometric, nutritional, and metabolic data in normal weight (control) or diet-induced obese (DIO) rats treated with NaCl or azoxymethane (AOM).
| Control | DIO | Two-way ANOVA | |||
|---|---|---|---|---|---|
| NaCl | AOM | NaCl | AOM | P value | |
| Anthropometric indices | |||||
| Body weight (g) | 700.4 ± 25.0 | 672.3 ± 33.7 | 810.1 ± 28.5∗∗ | 780.2 ± 38.5∗ | 0.0011§§ |
| Visceral fat mass (g) | 51.5 ± 5.0 | 34.7 ± 5.9# | 72.3 ± 7.6∗ | 64.1 ± 10.5∗ | 0.0009§§§ |
| Daily dietary intake | |||||
| Food intake (g) | 24.7 ± 1.6 | 99.6 ± 4.2 | 85.0 ± 5.0 | 20.3 ± 0.6∗ | 0.0041§§ |
| Total energy intake (kJ) | 364.6 ± 23.4 | 350.8 ± 14.2 | 445.8 ± 26 | 444.5 ± 12.6∗∗ | 0.0007§§§ |
| Energy intake from carbohydrates (KJ) | 240.7 ± 15.5 | 231.5 ± 9.2 | 102.6 ± 5.9∗∗ | 102.1 ± 2.9∗∗∗ | 0.0001§§§ |
| Energy intake from fat (KJ) | 36.4 ± 2.5 | 35.2 ± 1.3 | 267.5 ± 15.5∗∗∗ | 267.1 ± 7.5∗∗∗ | 0.0001§§§ |
| Energy intake from proteins (KJ) | 87.5 ± 5.4 | 84.1 ± 0.4 | 75.8 ± 4.6 | 75.8 ± 2.1 | 0.0237§ |
| Metabolic parameters | |||||
| Triacylglycerol (mmol/L) | 2.4 ± 0.3 | 2.0 ± 0.2 | 2.8 ± 0.2 | 2.5 ± 0.3 | 0.1025 |
| Total cholesterol (mmol/L) | 2.3 ± 0.2 | 1.9 ± 0.2 | 1.9 ± 0.1∗ | 2.0 ± 0.1 | 0.2738 |
| LDL (μmol/L) | 258.6 ± 0.1 | 259.6 ± 1.0 | 359.3 ± 19.0∗∗∗ | 349.0 ± 19.0∗∗∗ | 0.0001§§§ |
| HDL (mmol/L) | 2.0 ± 0.1 | 1.7 ± 0.2 | 1.5 ± 0.1∗∗ | 1.5 ± 0.1 | 0.0045§§ |
All data are expressed as mean ± SEM of n = 11–14 animals per group. Data of kilocalories (kcal) are given in parentheses. #P < 0.05, compared to NaCl-treated control group; ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001, compared to appropriate normal weight control; §P < 0.05, §§P < 0.01, and §§§P < 0.001, normal weight control groups compared to DIO groups.