Table 2.
Fitted parameter values for models of T1D/RA, T1D/T2D, T2D/RA, and GD/HT. H1 is the null hypothesis (under which σ3 = 1, ρ = 0) that SNPs differentiating the subgroups are not associated with the overall phenotype; H1 is the alternative (full model). p values for pseudo-likelihood ratio tests are also shown.
| π1 | π2 | π3 | σ2 | σ3 | τ | ρ | p-val | ||
|---|---|---|---|---|---|---|---|---|---|
| T1D/RA | H1 | 0.997 | 5.69 × 10-4 | 2.06 × 10-3 | 2.76 | 1.39 | 1.74 | 1.82 | 3.2 × 10-12 |
| H0 | 0.997 | 6.26 × 10-4 | 2.48 × 10-3 | 2.71 | - | 1.67 | - | ||
| T1D/T2D | H1 | 0.573 | 0.426 | 9.63 × 10-4 | 1.00 | 2.03 | 2.25 | 1.68 | 1.6 × 10-9 |
| H0 | 0.578 | 0.421 | 8.91 × 10-4 | 1.00 | - | 2.21 | - | ||
| T2D/RA | H1 | 0.573 | 0.426 | 8.71 × 10-4 | 1.00 | 2.23 | 1.75 | 1.69 | 5.1 × 10-9 |
| H0 | 0.910 | 8.05 × 10-4 | 0.0892 | 2.25 | - | 0.97 | - | ||
| GD/HT | H1 | 0.506 | 0.487 | 0.007 | 1.12 | 2.90 | 1.65 | 2.61 | 2.2 × 10-15 |
| H0 | 0.493 | 0.079 | 0.428 | 1.68 | - | 1.03 | - | ||