Table 1.
Study | Type | Age-median (years) |
Countries included |
Duration of study |
Sample size (n) |
Participants/health care service description |
||
---|---|---|---|---|---|---|---|---|
Intervention | Comparator | Intervention | Comparator | |||||
Chang et al. [21] | Cluster-randomized trial |
35.5 | 34.0 | South Africa | 27 months; May 2006–July 2008 |
1336 | Patients with Community- based peer health workers |
Control group- accessing standard of care |
Fatti et al. [45] | Cohort | 35.1 | 34.6 | South Africa | 69 months; January 2004– September 2010 |
66,953 | Patients who received community-based adherence support |
Patients without community- based adherence support |
Fatti et al. [46] | Cohort | 6.3 | 6.6 | South Africa | 69 months; January 2004– September 2010 |
4,853 | Patients who received community-based adherence support |
Patients without community- based adherence support |
Franke et al. [47] | Prospective cohort | 37.0 | 37.0 | Rwanda | 15 months; June 2007 to August 2008 |
610 | Community-Based Accompaniment |
Clinic-Based Care |
Grimsrud et al. [48] | Cohort | 33.9 | 33.2 | South Africa | 20 months; May 2012–December 2013 |
8,150 | Community based adherence club |
Community Health Centre |
Grimwood et al. [49•] | Cohort | 6.8 | 6.2 | South Africa | 57 months; January 2004– September 2009 |
3,563 | Children with patient advocates |
Children without patient advocates |
Jaffar et al. [25] | Cluster-randomized equivalence trial |
37.0 | 38.0 | Uganda | 48 months; February 2005– January 2009 |
1,453 | Home-based care | Facility based care |
Johnston et al. [50] | Retrospective cohort | 36.0 | 43.0 | South Africa | 75 months; January 2003– March 2010 |
417 | Community cohort | Workplace cohort |
Kipp et al. [51] | Cohort | 36.8 | 34.8 | Uganda | 15 months; March 2006–May 2007 |
385 | Centre/Community- based cohort |
Hospital-based cohort |
Kiweewa et al. [39] | Randomized controlled trial |
27.0 | 27.8 | Uganda | 29 months; May 2007–September 2009 |
92 | Nurse-Peer model | Doctor-Counsellor model |
Luque-Fernandez et al. [27] | Cohort | Not reported |
Not reported |
South Africa | 40 months; November 2007– February 2011 |
2,834 | Adherence clubs | Traditional clinic-based care |
Massavon et al. [52•] | Retrospective cohort |
91.0 months | 45.9 months | Uganda | 2003–2010 | 1,623 | Community home- based care approach |
Facility-based family- centred approach |
Mfinanga et al. [40•] | Open-label, randomized controlled trial |
38.0 35.0 |
37.0 35.0 |
Tanzania Zambia | 19 months; February, 2012–September, 2013 |
1,999 | Clinic plus community support |
Standard care |
Nachega et al. [29] | Open-label, randomized controlled trial |
35.7 | 36.7 | South Africa | 42 months; February 2005–July 2008 |
274 | Directly observed therapy (DOT-ART) arm |
Self-administered ART (Self-ART arm) |
Selke et al. [41] | Cluster randomized controlled clinical trial |
38.7 | 37.5 | Kenya | 26 months; March 2006– April 2008. |
208 | Community Care Coordinators arm patients |
Standard of Care arm patients |
Taiwo et al. [42] | Randomized controlled trial |
Not reported |
Not reported |
Nigeria | 19 months; June 2006– December 2007 |
499 | Treatment partner- assisted ART |
Patient-administered standard of care ART |
Gross et al. [44] | Randomized controlled trial |
38 | 37 | Botswana, Brazil, Haiti, Peru, South Africa, Uganda, Zambia, Zimbabwe |
30 months; April 2009– September 2011 |
259 | Partner-based modified directly observed therapy |
Standard of care |
Nakigozi et al. [30] | Randomized controlled trial |
37.6 | 37 | Uganda | 15 months; October 2010– January 2012 |
1,209 | Patient-selected care buddy |
Standard of care |
Kaihin et al. [53] | Cohort | 18.2 | 19.4 | Thailand | 4 months; April-July 2011 | 46 | Experimental Group (Empowerment Intervention) |
Control |
Kunutsor et al. [26] | Randomized controlled trial |
39.1 | 39.2 | Uganda | 8 months; March- September 2010 |
174 | Standard adherence intervention package plus treatment supporter intervention |
Standard intervention package |
Munoz et al. [54] | Cohort | 31.7 | 31.9 | Peru | 17 months; December 2005– April 2007 |
120 | Community-based accompaniment with supervised antiretrovirals |
Control |
Coker et al. [43]a | Randomized controlled trial |
Not reported |
Not reported |
Nigeria | 18 months; August 2006–January 2008 |
400 | Peer educators arm | Standard of care |
Coker et al. [43]b | Randomized controlled trial |
Not reported |
Not reported |
Nigeria | 18 months; August 2006–January 2008 |
400 | Home visits and peer educators arm |
Standard of care |