Table 1.
Demographic characteristics of the 25 TPIAT recipients with serum unmethylated INS DNA measures in the first 30 days post-TPIAT and/or at day 90 for comparison with metabolic parameters.
| Median | IQR or % | |
|---|---|---|
| Age (y) | 28.3 | 17.6, 44.6 |
| Pediatric, n (%) | 6 | 24% |
| Sex F, n (%) | 15 | 60% |
| BMI (kg/m2) | 25.0 | 21.5, 28.1 |
| HbA1c (%) pre-transplant | 5.3 | 5.1, 5.6 |
| Etiology, n (%) | ||
| Hereditary | 9 | 36% |
| Idiopathic | 8 | 32% |
| Pancreas Divsium | 4 | 16% |
| Other | 4 | 16% |
| IEQ total | 314,600 | 157,324, 453,300 |
| IEQ/kg | 3,912 | 2,677, 6,571 |
| IEQ total intraportal | 296,100 | 144,950, 388,200 |
| IEQ/kg intraportal | 3,912 | 2,181, 5,975 |
| Day 90 insulin use* (u/kg/d) | 0.27 | 0.12, 0.38 |
| Day 90 HbA1c | 6.0 | 5.6, 6.4 |
| Day 90 metabolic measures | ||
| AUC glucose (mg/dL*min) | 15870 | 13,725, 20,070 |
| AUC C-peptide (ng/mL*min) | 150 | 93, 306 |
| AIRg (mIU/mL*min) | 135 | 22, 233 |
| ACRg (ng/mL*min) | 7.55 | 1.40, 12.95 |
| AIRpot (mIU/mL) | 31.9 | 19.1, 65.7 |
| ACRpot (ng/mL) | 1.45 | 0.68, 3.08 |
Legend: IQR = interquartile range; IEQ = islet equivalents; AUC = area under the curve; AIR= acute insulin response to glucose; AIRpot = glucose potentiated acute insulin response to arginine; ACR = acute C-peptide response to glucose; ACRpot = glucose potentiated acute C-peptide response to arginine; Patients are maintained on insulin per protocol through day 90 to maintain euglycemia.