Table 3.

Clinical features of FXTAS dementia.^6,28,55

Clinical features
Prevalencea	10–31%
Cognitive domains affected
Executive function	Common, may be severe (inability to follow sequence of steps, difficulty shifting sets, impaired planning skills)
Memory	Common (retrieval and recall)
Attention	Relatively common
Personality/social cognition	Relatively common (disinhibition, apathy, loss of social decorum, loss of empathy)
Language	Rare (word-finding difficulties)
Visuospatial skills	Rare
Motor symptoms	Intention tremor, gait ataxia, parkinsonism
Neuropsychiatric symptoms
Anxietyb	15–16%
Depressionc	20–26%

^a12% in the present study; 31% in previous study⁶

^b15% in previous study by symptom review,⁶ 16% in the present study by Structured Clinical Interview for DSM-IV-TR (SCID)

^c20% in previous study by symptom review,⁶ 26% in the present study by SCID