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. 2017 Mar 20;8:136. doi: 10.3389/fphar.2017.00136

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Copyright © 2017 Munawar, Oriowo and Masocha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CB receptor and GPR55 antagonists on the antihyperalgesic effects of AEA and 2-AG in female BALB/c mice with ddC-induced thermal hyperalgesia at day 6 post-injection of ddC. Effects of (A) a CB1 receptor antagonist AM 251 and a CB2 receptor antagonist AM 630 on the antihyperalgesic effects of AEA, (B) a CB1 receptor antagonist AM 251 and a CB2 receptor antagonist AM 630 on the antihyperalgesic effects of 2-AG, and (C) GPR55 antagonists CID 16020046 and ML193 on the antihyperalgesic effects of 2-AG in BALB/c mice with ddC-induced thermal hyperalgesia 30 min after administration in the hot plate test. Each bar represents the mean ± SEM of values obtained from 8 to 16 animals.^∗∗p < 0.01 compared to drug vehicle at the same time point after treatment and ^##p < 0.01 to mice treated with AEA or 2-AG at the same time point after treatment (one-way ANOVA followed by Bonferroni’s Multiple Comparison Test).