Fig. 3.

Lipid metabolic pathways significantly altered in relation to bone marrow (BM) blasts at diagnosis. Blue bars = plasma metabolite level in controls, orange bars = plasma metabolite level in AML patients with intermediate (5–65%) BM blasts, red bars = plasma metabolite level in AML patients with high (> 80%) BM blasts. Error bars represent SD. For distribution of BM blasts see S3A. * means p < 0.05; ** means p < 0.01; *** means p < 0.001 for differences from controls. # means p < 0.05 for differences from intermediate BM blasts. Enzymes involved are 1, fatty acid elongase; 2, Δ⁵-desaturase; 3, COX-1 and COX-2; 4, PGE synthase; 5, carbonyl reductase 1; 6, 15-hydroxyprostaglandin dehydrogenase; 7, prostacyclin synthase; 8, spontaneous reaction; 9, spontaneous reaction; 10, prostaglandin D synthase; 11, spontaneous reaction; 12, 5-lipoxygenase; 13, arachidonic acid 11-oxidoreductase; 14, 15-lipoxygenase.