Table I.
Summary of various SPIONs used in this current study, dextran polymers used, polymer-to-iron ratio and the resultant hydrodynamic size and surface charge.
| Polymer type | Polymer-to-iron salt ratio | Hydrodynamic diameter (nm) | Surface charge (mV) | Intracellular iron content after 4 h labeling (pg) (25 µg/mL labeling) | Intracellular iron content after 24 h labeling (pg) (25 µg/mL labeling) |
|---|---|---|---|---|---|
| Dextran | 4:1 | 36.0 | −3.3 | N/A | 0.3 |
| CM-dextran | 4:1 | 34.3 | −11.6 | N/A | 0.5 |
| DEAE-dextran | 4:1 | 39.7 | +19.6 | N/A | 2.0 |
| DEAE-dextran | 1:1 | 47.3 | +17.7 | N/A | 2.3 |
| DEAE-dextran | 1:4 | 68.0 | +16.8 | 7.4 | 9.1 |
| Ferumoxide | Unknown | 115 | −6.7 | 2.2 | 4.9 |
| Ferumoxytol | Unknown | 24.9 | −24.2 | 0.1 | 0.9 |
Further information on commercial SPIONs can be found in a review by Li et al.[19].