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. 2017 Mar 20;7:44408. doi: 10.1038/srep44408

Figure 7. The mitochondrial apoptosis pathway is up-regulated in GSD1a.

Figure 7

(A) Mitochondrial membrane potential is reduced in G6PC KD AML-12 cells 72 hours after knockdown. (B) Cytosolic cytochrome c is increased in G6PC KD AML-12 cells. (C) Caspase 9 and caspase 3 cleavage is increased in G6PC KD AML-12 cells. (D,E) Caspase 9 (D) and caspase 3 (E) cleavage is increasted in G6PC KO mice. For all parts except A, n = 3, error bars represent SEM, and *represents p < 0.05. For A, n = 6.