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CD28− regulatory T-cells (Tregs)-like cells show evidence of advanced replicative senescence. Graphs show (A) expression of γH2AX, (B) T-cell receptor diversity, (C) expression of senescence-associated β-galactosidase (SABG), and (D) telomere lengths of CD28+ Tregs (green), CD28− Treg-like cells (blue), and naive CD45RA+ T-cells (gray). Mann–Whitney U test was used to assess differences between groups. *p < 0.05; n = 5.
